Pregnelone and sexual activity

In addition to its role as a natural hormone, pregnenolone has been used as a medication and supplement ; for information on pregnenolone as a medication or supplement, see the pregnenolone medication article. Neurosteroids affect synaptic functioning, are neuroprotective , and enhance myelinization. Pregnenolone and its sulfate ester may improve cognitive and memory function. Pregnenolone is an allosteric endocannabinoid , as it is a negative allosteric modulator of the CB 1 receptor. It prevents CB 1 receptor agonists like tetrahydrocannabinol , the main active constituent in cannabis , from fully activating the CB 1.
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Pregnenolone

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Pregnenolone - Wikipedia

The effects of age and sex on the levels of both steroids were investigated and the upper limits of normal in age groups were determined. The hydroxypregnenolone levels as a function of age were characterized by a statistically significant maximum at the age of 18 and 20 years followed by a local minimum at the age of 39 and 37 years and by a statistically insignificant local maximum at the age of 55 and 49 years in men and women, respectively. Pregnenolone age-dependence was similar and the statistically significant maximum was reached at the age of 17 and 16 years, the local minimum occurred at the age of 37 and 38 years and the second, statistically insignificant, local maximum at the age of 48 and 47 years in men and women, respectively. Both hydroxypregnenolone and pregnenolone in both sexes exhibited similarly shaped peaks with age. Both peaks of the polynomial fit in hydroxypregnenolone were more pronounced in men than in women The situation with pregnenolone was the opposite. Both peaks of the polynomial fit in pregnenolone were lower in men than in women 2.
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Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate

Neurosteroids may influence adult behavior and endocrine function since early in development. Pubertal onset in females was determined by monitoring the day of vaginal opening. After vaginal opening, the pattern of estrous cycle was monitored for three consecutive cycles. During adulthood, anxiety and locomotor activity were assessed with an automated elevated plus maze EPM and automated activity monitors, respectively.
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The effects of age and sex on the levels of both steroids were investigated and the upper limits of normal in age groups were determined. The hydroxypregnenolone levels as a function of age were characterized by a statistically significant maximum at the age of 18 and 20 years followed by a local minimum at the age of 39 and 37 years and by a statistically insignificant local maximum at the age of 55 and 49 years in men and women, respectively. Pregnenolone age-dependence was similar and the statistically significant maximum was reached at the age of 17 and 16 years, the local minimum occurred at the age of 37 and 38 years and the second, statistically insignificant, local maximum at the age of 48 and 47 years in men and women, respectively. Both hydroxypregnenolone and pregnenolone in both sexes exhibited similarly shaped peaks with age.
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